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Comment
. 2012 Feb 8;20(2):197-8.
doi: 10.1016/j.str.2012.01.013.

Host glycan recognition by a pore forming toxin

Samuel Bouyain  1 , Brian V Geisbrecht
Affiliations
Comment

Host glycan recognition by a pore forming toxin

Samuel Bouyain et al. Structure. .

Abstract

An exposed F-type lectin domain fused to the N-terminus of a cholesterol-dependent cytolysin scaffold allows Streptococcus mitis lectinolysin to cluster at fucose-rich sites on target cell membranes, thereby leading to increased pore-forming toxin activity. In this issue of Structure, Feil and coworkers define the structural basis for lectinolysin glycan-binding specificity.

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References

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