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Comment
. 2012 Feb 8;20(2):199-200.
doi: 10.1016/j.str.2012.01.015.

The porous borders of the protein world

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The porous borders of the protein world

Matthew H J Cordes et al. Structure. .
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Abstract

Fold switching may play a role in the evolution of new protein folds and functions. He et al., in this issue of Structure, use protein design to illustrate that the same drastic change in a protein fold can occur via multiple different mutational pathways.

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