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Review
. 2012 Jan;35(1):9-21.
doi: 10.1179/2045772311Y.0000000042.

Osteoporosis in paediatric patients with spina bifida

Humberto Marreiros  1 , Clara Loff, Eulalia Calado
Affiliations
Review

Osteoporosis in paediatric patients with spina bifida

Humberto Marreiros et al. J Spinal Cord Med. 2012 Jan.

Erratum in

  • J Spinal Cord Med. 2012 Mar;35(2):129-30. Marreiros, Humberto Filipe [corrected to Marreiros, Humberto]

Abstract

The prevalence and morbidity associated with osteoporosis and fractures in patients with spina bifida (SB) highlight the importance of osteoporosis prevention and treatment in early childhood; however, the issue has received little attention. The method for the selection of appropriate patients for drug treatment has not been clarified.

Objective: To review the literature concerning fracture risks and low bone density in paediatric patients with SB. We looked for studies describing state-of-the-art treatments and for prevention of secondary osteoporosis.

Methods: Articles were identified through a search in the electronic database (PUBMED) supplemented with reviews of the reference lists of selected papers. The main outcome measures were incidence of fractures and risk factors for fracture, an association between bone mineral density (BMD) and occurrence of fracture, risk factors of low BMD, and effects of pharmacological and non-pharmacological treatments on BMD and on the incidence of fractures. We considered as a secondary outcome the occurrence of fractures in relation to the mechanism of injury.

Results: Results indicated that patients with SB are at increased risk for fractures and low BMD. Risk factors that may predispose patients to fractures include higher levels of neurological involvement, non-ambulatory status, physical inactivity, hypercalciuria, higher body fat levels, contractures, and a previous spontaneous fracture. Limitations were observed in the number and quality of studies concerning osteoporosis prevention and treatment in paediatric patients with SB. The safety and efficiency of drugs to treat osteoporosis in adults have not been evaluated satisfactorily in children with SB.

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References

    1. Parsch K. Origin and treatment of fractures in spina bifida. Eur J Pediatr Surg 1991;1(5):298–305 - PubMed
    1. Molnar GE, Murphy KP. Spina bifida. In: Molnar GE, Alexander MA. (eds.) Pediatric rehabilitation. Philadelphia, PA: Hanley & Belfus; 1999. p. 219–44
    1. Anschuetz RH, Freehafer AA, Shaffer JW, Dixon MS., Jr. Severe fracture complications in myelodysplasia. J Pediatr Orthop 1984;4(1):22–4 - PubMed
    1. Marreiros H, Monteiro L, Loff C, Calado E. Fractures in children and adolescents with Spina Bifida – experience of a Portuguese tertiary care hospital. Dev Med Child Neurol 2010;52(8):754–9 - PubMed
    1. Quan A, Adams R, Ekmark E, Baum M. Bone mineral density in children with myelomeningocele. Pediatrics 1998;102(3):E34. - PubMed