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. 2012 Feb 13;14(1):R28.
doi: 10.1186/bcr3113.

PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups

Magdalena Cizkova  1 , Aurélie Susini, Sophie Vacher, Géraldine Cizeron-Clairac, Catherine Andrieu, Keltouma Driouch, Emmanuelle Fourme, Rosette Lidereau, Ivan Bièche
Affiliations

PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups

Magdalena Cizkova et al. Breast Cancer Res. .

Abstract

Introduction: PIK3CA is the oncogene showing the highest frequency of gain-of-function mutations in breast cancer, but the prognostic value of PIK3CA mutation status is controversial.

Methods: We investigated the prognostic significance of PIK3CA mutation status in a series of 452 patients with unilateral invasive primary breast cancer and known long-term outcome (median follow-up 10 years).

Results: PIK3CA mutations were identified in 151 tumors (33.4%). The frequency of PIK3CA mutations differed markedly according to hormone receptor (estrogen receptor alpha [ERα] and progesterone receptor [PR]) and ERBB2 status, ranging from 12.5% in the triple-negative subgroup (ER-/PR-/ERBB2-) to 41.1% in the HR+/ERBB2- subgroup. PIK3CA mutation was associated with significantly longer metastasis-free survival in the overall population (P = 0.0056), and especially in the PR-positive and ERBB2-positive subgroups. In Cox multivariate regression analysis, the prognostic significance of PIK3CA mutation status persisted only in the ERBB2-positive subgroup.

Conclusions: This study confirms the high prevalence of PIK3CA mutations in breast cancer. PIK3CA mutation is an emerging tumor marker which might become used in treatment-choosing process. The independent prognostic value of PIK3CA mutation status in ERBB2-positive breast cancer patients should be now confirmed in larger series of patients included in randomized prospective ERBB2-based clinical trials.

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Figures

Figure 1
Figure 1
Whole population survival curves. (a) Metastasis-free survival curves of patients with PIK3CA wild-type and -mutated tumors. (b) Metastasis-free survival curves of patients with exon 9 PIK3CA-mutated tumors, exon 20 PIK3CA-mutated tumors, and PIK3CA wild-type tumors. Comparison of these curves did not show any statistically significant difference. PIK3CA, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide gene.
Figure 2
Figure 2
Subgroup analysis survival curves. (a) Metastasis-free survival curves of progesterone receptor-positive (PR+) patients with PIK3CA wild-type and -mutated tumors. (b) Metastasis-free survival curves of ERBB2+ patients with PIK3CA wild-type and -mutated tumors. PIK3CA, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide gene.
See this image and copyright information in PMC

References

    1. Zhao L, Vogt PK. Class I PI3K in oncogenic cellular transformation. Oncogene. 2008;27:5486–5496. doi: 10.1038/onc.2008.244. - DOI - PMC - PubMed
    1. Dillon RL, White DE, Muller WJ. The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Oncogene. 2007;26:1338–1345. doi: 10.1038/sj.onc.1210202. - DOI - PubMed
    1. Samuels Y, Diaz LA Jr, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell. 2005;7:561–573. doi: 10.1016/j.ccr.2005.05.014. - DOI - PubMed
    1. Karakas B, Bachman KE, Park BH. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer. 2006;94:455–459. doi: 10.1038/sj.bjc.6602970. - DOI - PMC - PubMed
    1. Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci USA. 2005;102:18443–18448. doi: 10.1073/pnas.0508988102. - DOI - PMC - PubMed

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