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. 2012 Mar 27;140(2):424-7.
doi: 10.1016/j.jep.2012.01.049. Epub 2012 Feb 6.

Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract in Wistar rats

Arul Amuthan  1 , Bharti Chogtu, K L Bairy, Sudhakar, Mungli Prakash
Affiliations

Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract in Wistar rats

Arul Amuthan et al. J Ethnopharmacol. .

Abstract

Ethnopharmacological relevance: Traditional Siddha medicine literature claims that the Amaranthus spinosus Linn. (family: Amaranthaceae) whole plant possesses diuretic property.

Aim of the study: To evaluate the diuretic potential of Amaranthus spinosus aqueous extract (ASAE) in rats.

Material and methods: Different concentrations of ASAE (200, 500, 1000, 1500mg/kg), thiazide (10mg/kg) and vehicle were orally administered to rats (n=6 animals per group) and their urine output was collected after 24h. Volume, pH, Na(+), K(+) and Cl(-) concentrations of urine were estimated.

Results: ASAE produced increase in Na(+), K(+), Cl(-) excretion, caused alkalinization of urine, showed strong saluretic activity and carbonic anhydrase inhibition activity. These effects were observed predominantly at 500mg/kg dose and there was no dose-response relationship.

Conclusion: Our study strongly suggests that the Amaranthus spinosus is acting as a thiazide like diuretic with carbonic anhydrase inhibitory activity which restates the claim as diuretic herb in Siddha medicine.

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