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Comment
. 2012 Mar;4(3):165-7.
doi: 10.1002/emmm.201200202. Epub 2012 Feb 13.

p63 and FGFR: when development meets proliferation

G Paolo Dotto  1
Affiliations
Comment

p63 and FGFR: when development meets proliferation

G Paolo Dotto. EMBO Mol Med. 2012 Mar.
No abstract available

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Figures

Figure 1
Figure 1. Impact of p63-SAM mutations on palate development

  1. ΔNp63α functions as a positive determinant of FGFR2 and FGFR3 expression. Mutations found in AEC syndrome are sufficient to suppress, in a heterozygous state, FGFR2 and FGFR3 expression. This causes an impairment of proliferation in embryonic ectodermal cells.

  2. p63 is interconnected with several pathways that are required for one or more steps of secondary palate development as recently reviewed (Dixon et al, 2011).

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References

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Supplementary concepts