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Case Reports
. 2012 Feb;130(2):246-8.
doi: 10.1001/archopthalmol.2011.1588.

Residual intraretinal retinoblastoma after chemoreduction failure

Christopher K Hwang  1 , Thomas M Aaberg Jr, Patricia Chevez-Barrios, Elizabeth Verner-Cole, Dan S Gombos, Evelyn Paysse, Murali Chintagumpala, Weiqing Gao, Hans E Grossniklaus
Affiliations
Case Reports

Residual intraretinal retinoblastoma after chemoreduction failure

Christopher K Hwang et al. Arch Ophthalmol. 2012 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Ultrasound images and fundus photos from case 1. A: Ultrasound image at presentation shows superior endophytic tumor (arrow). B: Ultrasound image immediately before enucleation shows recurrent superior endophytic tumor (arrow). C: Fundus photo at presentation shows superior endophytic tumor (arrow). D: Fundus photo immediately before enucleation shows recurrent inferior endophytic tumor (arrow).
Figure 2
Figure 2
Fundus photos from case 2. A: Fundus photo at presentation shows superior and inferior temporal tumors (white arrows). B: Fundus photo at two months before enucleation shows flattening of the main tumor (white arrow) and residual intraretinal tumor (black arrow). C: Fundus photo immediately before enucleation shows the main tumor that has thickened (white arrow), residual intraretinal tumor (black arrow), and vitreous seeds.
Figure 3
Figure 3
Vasculature characteristics of diffuse infiltrating retinoblastoma from case 1. A and B: The tumor diffusely infiltrates the retina and surrounds mature blood vessels (arrows) in the posterior retina. (hematoxylin and eosin, 10X and 25X) C and D: Blood vessels within the the intraretinal tumor stain with CD31 (green) and smooth muscle actin antibodies (yellow), which are markers for mature vessels. Numerous mature vessels (arrows) were detected in the tumor. (original magnification 10X) E: Blood vessels in the tumor failed to stain with endoglin/CD105 antibody (red), which is a marker for new blood vessels. No immature vessels were detected in the tumor. (original magnification 10X). Positive controls were used to validate the antibody for endoglin (CD105).
Figure 4
Figure 4
Vasculature characteristics of diffuse infiltrating retinoblastoma from case 2. A and B: The tumor diffusely infiltrates the retina and surrounds mature blood vessels (arrows) in the posterior retina. (hematoxylin and eosin, 10X and 25X) C and D: Blood vessels within the the intraretinal tumor stain with CD31 (green) and smooth muscle actin antibodies (yellow), which are markers for mature vessels. Numerous mature vessels (arrows) were detected in the tumor. (original magnification 20X) E: Blood vessels in the tumor failed to stain with endoglin/CD105 antibody (red), which is a marker for new blood vessels. No immature vessels were detected in the tumor. (original magnification 20X). Positive controls were used to validate the antibody for endoglin (CD105).
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