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Review
. 2012;17(2):80-3.
doi: 10.1179/1351000212Y.0000000002. Epub 2012 Feb 2.

Redox-mediated programed death of myocardial cells after cardiac arrest and cardiopulmonary resuscitation

Athanasios Chalkias  1 , Theodoros Xanthos
Affiliations
Review

Redox-mediated programed death of myocardial cells after cardiac arrest and cardiopulmonary resuscitation

Athanasios Chalkias et al. Redox Rep. 2012.

Abstract

Besides the fact that prolonged whole-body ischemia causes tissue and organ injury during cardiac arrest, additional damage occurs after the restoration of spontaneous circulation, during which the reperfusion activates a host of intracellular responses. These responses may lead to an increased threshold of oxidant-mediated injury and redox-mediated programed cell death in the stunned myocardium. The aim of this article is to summarize the major intracellular responses occurring from the onset of cardiac arrest until the post-resuscitation period that may lead to redox-mediated programed death of myocardial cells.

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Figures

Figure 1.
Figure 1.
Activation of programed cell-death pathways during the cardiac arrest interval.
Figure 2.
Figure 2.
Activation of programed cell death during the post-resuscitation period. PMC, protein kinase C family.
See this image and copyright information in PMC

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