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Editorial
. 2012 Mar 1;11(5):833-4.
doi: 10.4161/cc.11.5.19596. Epub 2012 Mar 1.

Coreceptor gene "imprinting:" a genetic solution to a developmental dilemma in T cells

Stanley Adoro, Jung-Hyun Park, Alfred Singer
Editorial

Coreceptor gene "imprinting:" a genetic solution to a developmental dilemma in T cells

Stanley Adoro et al. Cell Cycle. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic of coreceptor gene imprinting. Helper vs. cytotoxic lineage fate is determined by Cd4 and Cd8 coreceptor gene loci and not by the coreceptor protein each encodes. CD4 coreceptor proteins promote thymic generation of mature CD4 T cells with MHCII-specific TCRs. Importantly, however, CD4 proteins encoded in the Cd4 gene locus induce CD4 T cells to acquire helper function (A), whereas CD4 proteins encoded in the Cd8 gene locus induce CD4 T cells to acquire cytotoxic function (B).
See this image and copyright information in PMC

Comment on

  • Cell Cycle.

References

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