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Review
. 2012 Mar 1;11(5):871-6.
doi: 10.4161/cc.11.5.19300. Epub 2012 Mar 1.

The role of TRADD in death receptor signaling

Yelena L Pobezinskaya  1 , Zhenggang Liu
Affiliations
Review

The role of TRADD in death receptor signaling

Yelena L Pobezinskaya et al. Cell Cycle. .

Abstract

TRADD (TNFR1-associated death domain protein) was initially identified as an adaptor molecule that transduces the signal downstream of the TNFR1 (tumor necrosis factor receptor 1). TNFR1 belongs to the so-called death receptor (DR) family of receptors that depending on the context can induce either apoptosis or proliferation, as well as NF-κB and MAP kinase activation. The receptors of this group contain death domain (DD) that is necessary for the induction of apoptosis. This review summarizes the recent advances in the field of DR signaling and in particular the role of TRADD.

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References

    1. Lavrik I, Golks A, Krammer PH. Death receptor signaling. J Cell Sci. 2005;118:265–7. doi: 10.1242/jcs.01610. - DOI - PubMed
    1. Itoh N, Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem. 1993;268:10932–7. - PubMed
    1. Tartaglia LA, Ayres TM, Wong GH, Goeddel DV. A novel domain within the 55 kd TNF receptor signals cell death. Cell. 1993;74:845–53. doi: 10.1016/0092-8674(93)90464-2. - DOI - PubMed
    1. Chinnaiyan AM, O’Rourke K, Tewari M, Dixit VM. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81:505–12. doi: 10.1016/0092-8674(95)90071-3. - DOI - PubMed
    1. Hsu H, Xiong J, Goeddel DV. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell. 1995;81:495–504. doi: 10.1016/0092-8674(95)90070-5. - DOI - PubMed

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