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Comment
. 2012 Feb 14:8:569.
doi: 10.1038/msb.2012.2.

miRNAs versus oncogenes: the power of social networking

Marcos Malumbres  1
Affiliations
Comment

miRNAs versus oncogenes: the power of social networking

Marcos Malumbres. Mol Syst Biol. .
No abstract available

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Conflict of interest statement

The author declares that he has no conflict of interest.

Figures

Figure 1
Figure 1
Control of the EGFR pathway and cell cycle entry by miRNAs. The EGF receptor uses several downstream pathways to drive cell cycle progression. Similarly, miRNAs simultaneously modulate several of these downstream pathways to effect cell cycle progression. For instance, miR-124 co-downregulates AKT2, p38MAPK and STAT3 to inhibit the EGFR pathway leading to CDK downregulation, p27Kip1 upregulation and cell cycle inhibition. miR-147 also participates in AKT2 downregulation and simultaneously represses Cyclins (Cyc). These two examples show how a single miRNA can target several components of a signaling pathway and how two miRNAs can co-regulate the same target. These data also suggest the therapeutic value of miR-124 and miR-147 in treating EGFR-dependent tumors. Only a few representative molecules are shown for clarity.
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