Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Jul;4(7):593-605.
doi: 10.1039/c2mt00185c. Epub 2012 Feb 15.

Cellular transport and homeostasis of essential and nonessential metals

Ebany J Martinez-Finley  1 , Sudipta Chakraborty, Stephanie J B Fretham, Michael Aschner
Affiliations
Review

Cellular transport and homeostasis of essential and nonessential metals

Ebany J Martinez-Finley et al. Metallomics. 2012 Jul.

Abstract

Metals can have a number of detrimental or beneficial effects in the cell, but first they must get in. Organisms have evolved transport mechanisms to get metals that are required, or essential into the cell. Nonessential metals often enter the cell through use of the machinery provided for essential metals. Much work has been done to advance our understanding of how these metals are transported across plasma and organelle membranes. This review provides an overview of essential and nonessential metal transport and homeostatic processes.

PubMed Disclaimer

Figures

Fig 1
Fig 1
Cellular Metal Transport. Essential metals are represented in green and non-essential metals are represented in red. Primary metal transporters are illustrated in bold, while secondary metal transporters are italicized.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Waldron KJ, Rutherford JC, Ford D, Robinson NJ. Nature. 2009;460:823–830. - PubMed
    1. Andreini C, Bertini I, Cavallaro G, Holliday GL, Thornton JM. J Biol Inorg Chem. 2008;13:1205–1218. - PubMed
    1. Martinez-Finley EJ, Aschner M. J Toxicol. 2011;2011:895236. - PMC - PubMed
    1. I. o. M. Food and Nutrition Board. 2006:304–311.
    1. Syracuse Research Corporation., United States. Dept. of Health and Human Services., United States. Agency for Toxic Substances and Disease Registry. and United States. Atlanta, GA: Public Health Service., Agency for Toxic Substances and Disease Registry; p. v.

Publication types