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. 2012 Apr;84(4):672-8.
doi: 10.1002/jmv.22247.

The epidemiology and etiology of influenza-like illness in Chinese children from 2008 to 2010

Jinsong Peng  1 , Wenhua Kong, Deyin Guo, Manqing Liu, Ying Wang, Honghao Zhu, Beibei Pang, Xiaoping Miao, Bin Yu, Tongyong Luo, Quan Hu, Dunjin Zhou
Affiliations

The epidemiology and etiology of influenza-like illness in Chinese children from 2008 to 2010

Jinsong Peng et al. J Med Virol. 2012 Apr.

Abstract

Influenza-like illness can be caused by a wide range of respiratory viruses. In order to investigate the epidemiology of viral pathogens related to influenza-like illness in children of Wuhan, the largest city in central China, throat swab samples were collected from 1,472 young patients, from July 2008 to June 2010, before and after the occurrence of the 2009 pandemic influenza A (H1N1) virus (pH1N1). It was found that 923 patients (62.7%) were positive for at least 1 virus and 90 patients (9.8%) were detected for multiple (≥2) respiratory viruses by real-time PCR detection of 16 viruses. Seasonal influenza A virus was the predominant pathogen among all the 16 viruses with a positive rate of 13.3% (196/1,472), which was followed by pH1N1 (159/1,472). It was also noted that the viral distribution pattern in Wuhan changed upon the introduction of the pH1N1 virus.

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Figures

Figure 1
Figure 1
Patients' monthly distribution and virus detection rate from July 2008 to June 2010.
Figure 2
Figure 2
Monthly distribution of respiratory viruses detected by real‐time PCR. A: FLUAV, seasonal influenza A virus; FLUBV, influenza B virus; pH1N1, the 2009 pandemic influenza A(H1N1) virus; B: RSV, respiratory syncytial virus; HMPV, human metapneumovirus; HCoV, human coronavirus; C: HRV, human rhinovirus; HAdV, human adenovirus; PIV, parainfluenza virus; HBoV, human bocavirus.
Figure 3
Figure 3
Viral etiology before and after the appearance of the novel pH1N1 virus in Wuhan. HBoV, human bocavirus; FLUAV, seasonal influenza A virus; FLUBV, influenza B virus; pH1N1, the 2009 pandemic influenza A(H1N1) virus; RSV, respiratory syncytial virus; HAdV, human adenovirus; Rhino, human rhinovirus; HMPV, human metapneumovirus; PIV, parainfluenza virus; HCoV, human coronavirus.
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