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Comparative Study
. 1990 Nov;10(11):6051-4.
doi: 10.1128/mcb.10.11.6051-6054.1990.

Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins

R M Young  1 , A E Mendoza, T Collins, S H Orkin
Affiliations
Comparative Study

Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins

R M Young et al. Mol Cell Biol. 1990 Nov.

Abstract

Two platelet-derived growth factor A-chain proteins, termed short and long A chains, are generated as a result of alternative mRNA splicing of exon 6 of the A-chain gene. S1 nuclease mapping and polymerase chain reaction analyses demonstrate that both short and long A-chain transcripts are expressed in a variety of normal tissues. In addition, immunohistochemical localization of long A-chain protein reveals a cellular distribution identical to that observed with platelet-derived growth factor heteroserum.

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