[Immunohistology of Hodgkin's disease. Use of monoclonal antibodies in the analysis of the pathomorphology of Hodgkin's disease]

Abstract

Author studied cryostatic sections of lymph node biopsy of 45 untreated patients suffering in lymphogranulomatosis by known T and B lymphocyte, macrophage-histiocyte, Ia and HLA-DR and transferrine receptor specific monoclonal antibodies (moats). In HK-LP, HK-NS, HK-MC and HK-LD the infiltrations were formed by phenotyped lymphocytes contrary to HK-NP, where HK nodules were composed of B-cells. In HK-LPs T lymphocytes were of T-helper phenotypes, and these T-cells were observed in cases of HH-NS and HK-MC, abounding in lymphocytes, besides a few T-suppressor cells. The number of lymphocyte of latter type increased in HK-NS and and HK-MC, poor in lymphocytes and in HK-LD. The giant cells had positive reaction with Leu3a, Leu5, OKIa, HLA-DR and transferrine receptor specific moats. SR cells are such anaplasic cells or probably tumorous cells developed by cell hybridization, which are able to antigen expression characteristic of various hemopoietic cell line and of activated cells, respectively.