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. 2012 Dec;9(4):305-10.
doi: 10.2174/157016312803305951.

Convection enhanced delivery of macromolecules for brain tumors

Ankit I Mehta  1 , Bryan D Choi, Divya Ajay, Raghu Raghavan, Martin Brady, Allan H Friedman, Ira Pastan, Darell D Bigner, John H Sampson
Affiliations

Convection enhanced delivery of macromolecules for brain tumors

Ankit I Mehta et al. Curr Drug Discov Technol. 2012 Dec.

Abstract

The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.

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Conflict of interest statement

CONFLICT OF INTEREST

None declared.

Figures

Fig. (1) –
Fig. (1) –
Diagram of CED Catheter
See this image and copyright information in PMC

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