Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 May;17(3):240-7.
doi: 10.3109/1354750X.2012.658863. Epub 2012 Feb 18.

GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh

Ema G Rodrigues  1 , Molly Kile, Elaine Hoffman, Quazi Quamruzzaman, Mahmuder Rahman, Golam Mahiuddin, Yumei Hsueh, David C Christiani
Affiliations

GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh

Ema G Rodrigues et al. Biomarkers. 2012 May.

Abstract

We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Four SNPs were assessed in these genes. A pathway analysis evaluated the association between urinary arsenic metabolites and SNPs. GSTO1 rs4925 homozygous wild type was significantly associated with higher monomethylarsonic acid (MMA) and dimethylarsinic acid urinary concentrations, whereas wild-type AS3MT rs11191439 had significantly lower levels of As(III) and MMA. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Arsenic metabolism pathway illustrating the relationships between water arsenic levels and urinary arsenic metabolites while adjusting for covariates (Model 1). The standardized path coefficients (r) are listed for each path and effects of the SNPs. Only the SNPs that were significant at the 0.05 level remained in the path analysis.
Figure 2
Figure 2
Arsenic metabolism pathway illustrating the relationships between water arsenic levels and urinary arsenic metabolites, including the main effects of genetic SNPs and covariates (Model 2). The standardized path coefficients (r) are listed for each path and effects of the SNPs. Only the SNPs that were significant at the 0.05 level remained in the path analysis.
See this image and copyright information in PMC

References

    1. AHSAN H, CHEN Y, KIBRIYA MG, SLAVKOVICH V, PARVEZ F, JASMINE F, GAMBLE MV, GRAZIANO JH. Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Cancer Epidemiol Biomarkers Prev. 2007;16:1270–8. - PubMed
    1. BRETON CV, ZHOU W, KILE ML, HOUSEMAN EA, QUAMRUZZAMAN Q, RAHMAN M, MAHIUDDIN G, CHRISTIANI DC. Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes. Carcinogenesis. 2007;28:1520–5. - PubMed
    1. CHALLENGER F. Biological Methylation. Chemical Reviews. 1945;36:315–361.
    1. CHEN YC, GUO YL, SU HJ, HSUEH YM, SMITH TJ, RYAN LM, LEE MS, CHAO SC, LEE JY, CHRISTIANI DC. Arsenic methylation and skin cancer risk in southwestern Taiwan. J Occup Environ Med. 2003;45:241–8. - PubMed
    1. FUJIHARA J, SOEJIMA M, KODA Y, KUNITO T, TAKESHITA H. Asian specific low mutation frequencies of the M287T polymorphism in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene. Mutat Res. 2008;654:158–61. - PubMed

Publication types