Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Feb 14;21(2):137-8.
doi: 10.1016/j.ccr.2012.01.013.

Three down and one to go: modeling medulloblastoma subgroups

Charles G Eberhart  1
Affiliations
Comment

Three down and one to go: modeling medulloblastoma subgroups

Charles G Eberhart. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Pei et al. and Kawauchi et al. describe murine models of an aggressive medulloblastoma subtype driven by Myc. These tumors have a cellular origin, microscopic appearance, and molecular profile distinct from those of three other major subgroups. Thus, the models fill a significant clinical need.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Medulloblastoma Subgroups
Transcriptional profiling supports the existence of four main medulloblastoma subgroups that differ with respect to their common microscopic appearance and clinical associations. The cartoons below depict a classic medulloblastoma comprised of heterogenous embryonal cells, a desmoplastic/nodular tumor with a central region of neuronal differentiation, and a large cell anaplastic medulloblastoma with increased nuclear size and pronounced cellular molding/engulfment.
See this image and copyright information in PMC

Comment on

  • An animal model of MYC-driven medulloblastoma.
    Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, Northcott PA, Taylor MD, Pfister SM, Febbo PG, Wechsler-Reya RJ. Pei Y, et al. Cancer Cell. 2012 Feb 14;21(2):155-67. doi: 10.1016/j.ccr.2011.12.021. Cancer Cell. 2012. PMID: 22340590 Free PMC article.
  • A mouse model of the most aggressive subgroup of human medulloblastoma.
    Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF. Kawauchi D, et al. Cancer Cell. 2012 Feb 14;21(2):168-80. doi: 10.1016/j.ccr.2011.12.023. Cancer Cell. 2012. PMID: 22340591 Free PMC article.

References

    1. Cho YJ, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Berhoukim R, Amani V, Goumnerova L, Eberhart CG, et al. J. Clin. Oncol. 2011;29:1424–1430. - PMC - PubMed
    1. Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, et al. Nature. 2010;468:1095–1099. - PMC - PubMed
    1. Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg JE, Gao C, Finkelstein D, Qu C, Pounds S. Cancer Cell. 2012;21:168–180. this issue. - PMC - PubMed
    1. Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S, Bouffet E, Clifford SC, Hawkins CE, French P, et al. J. Clin. Oncol. 2011;29:1408–1414. - PMC - PubMed
    1. Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL. Cancer Cell. 2012;21:155–167. this issue. - PMC - PubMed

LinkOut - more resources