Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Feb 14;21(2):145-7.
doi: 10.1016/j.ccr.2012.01.018.

PI3King on MYCN to improve neuroblastoma therapeutics

Michael D Hogarty  1 , John M Maris
Affiliations
Free article
Comment

PI3King on MYCN to improve neuroblastoma therapeutics

Michael D Hogarty et al. Cancer Cell. .
Free article

Abstract

MYCN is an oncogenic driver of childhood neuroblastoma, a frequently lethal pediatric tumor. In a recent paper in Science Translational Medicine, Chanthery and colleagues demonstrate that PI3K inhibition leads to the dual therapeutic benefits of enhanced MYCN degradation and loss of a paracrine angiogenic signal mediated by MYCN.

PubMed Disclaimer

Comment on

LinkOut - more resources