Comment
doi: 10.1016/j.chom.2012.02.001.
SAMHD1 Joins the red Queen's court
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- PMID: 22341459
- DOI: 10.1016/j.chom.2012.02.001
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Comment
SAMHD1 Joins the red Queen's court
Cell Host Microbe.
.
Free article
Abstract
The host restriction factor SAMHD1 hinders lentiviral infection of myeloid cells, a function counteracted by the viral protein Vpx. Two papers in this issue of Cell Host & Microbe document the genetic conflict between SAMHD1 and the Vpr/Vpx proteins, which has subjected SAMHD1 to intense periods of diversifying selection through primate evolution.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.Cell Host Microbe. 2012 Feb 16;11(2):194-204. doi: 10.1016/j.chom.2012.01.004. Epub 2012 Jan 26. Cell Host Microbe. 2012. PMID: 22284954 Free PMC article.
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Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein.Cell Host Microbe. 2012 Feb 16;11(2):205-17. doi: 10.1016/j.chom.2012.01.007. Epub 2012 Feb 1. Cell Host Microbe. 2012. PMID: 22305291 Free PMC article.
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