Comment
doi: 10.1016/j.cmet.2012.01.014.
Epub 2012 Feb 16.
Transmitter time: synaptic plasticity and metabolic memory in the hypothalamus
Affiliations
- PMID: 22342702
- DOI: 10.1016/j.cmet.2012.01.014
Item in Clipboard
Comment
Transmitter time: synaptic plasticity and metabolic memory in the hypothalamus
Cell Metab.
.
Free article
Abstract
Hunger elicits feeding behavior by activating Agouti-related peptide (AgRP) neurons. Two recent studies show how fasting, or the hunger hormone ghrelin, promote excitatory glutamate release onto AgRP neurons (Yang et al., 2011) and increase postsynaptic glutamate receptor-mediated drive (Liu et al., 2012).
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
-
Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop.Cell. 2011 Sep 16;146(6):992-1003. doi: 10.1016/j.cell.2011.07.039. Cell. 2011. PMID: 21925320 Free PMC article.
-
Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone.Neuron. 2012 Feb 9;73(3):511-22. doi: 10.1016/j.neuron.2011.11.027. Neuron. 2012. PMID: 22325203 Free PMC article.
Publication types
LinkOut - more resources
Full Text Sources
