[Recurring arterial thrombosis in the adult during a nephrotic syndrome. Report of a case and review of the literature]

Abstract

A 55 year old male with idiopathic nephrotic syndrome (minimal glomerular changes at light microscopy) developed recurrent arterial thrombosis (aortic, popliteal and prosthetic) combined with recurrent proteinuria. Fourty nine cases of adult arterial thrombosis associated with nephrotic syndrome are reviewed. This complication mainly affects the coronary, iliac and femoral, renal and cerebral arteries. Any type of nephrotic syndrome can be involved. The hypercoagulable state predisposes to thromboembolic events. Corticosteroid induced thrombotic episodes have been described during nephrotic syndrome. Therefore anticoagulant therapy is mandatory when steroid therapy is used.