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Review
. 2012 Jul;23(5):509-14.
doi: 10.1016/j.semcdb.2012.01.014. Epub 2012 Feb 8.

Selective protein degradation in cell signalling

Affiliations
Review

Selective protein degradation in cell signalling

Han Liu et al. Semin Cell Dev Biol. 2012 Jul.

Abstract

A variety of post-translational modifications such as phosphorylation, acetylation and ubiquitylation transduce cellular signals, which culminate in changes in gene transcription. In this article we examine the ways in which selective protein degradation provides an extra dimension to the regulation of such signalling cascades. We discuss (i) how both lysosomal and proteasomal systems are used to attenuate kinase and rho family GTPase signalling, thereby coupling activation with degradation, (ii) signal propagation contingent upon the selective degradation of inhibitory components, exemplified by the degradation of IκB to activate NF-κB signalling, and (iii) tonic suppression of signalling pathways by turnover of the transcription factors β-catenin and p53.

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