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. 2012 Feb 17;17(2):1992-9.
doi: 10.3390/molecules17021992.

Allylic alkylations catalyzed by palladium-bis(oxazoline) complexes derived from heteroarylidene malonate derivatives

Lei Liu  1 , Hongli Ma, Bin Fu
Affiliations

Allylic alkylations catalyzed by palladium-bis(oxazoline) complexes derived from heteroarylidene malonate derivatives

Lei Liu et al. Molecules. .

Abstract

A series of simple heteroarylidene malonate-type bis(oxazoline) ligands 4 and 5 were applied to the palladium-catalyzed allylic alkylation reaction, and the ligand 4a bearing a phenyl group afforded excellent enantioselectivity (up to 96% ee) for the allylic alkylation product. Other substrates were also examined, giving the allylic alkylated products in high yield but with poor ee values.

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Figures

Figure 1
Figure 1
The alkylidene and arylidene malonate-type bis(oxazoline) ligands.
Scheme 1
Scheme 1
The model reaction of palladium-catalyzed asymmetric allylic alkylation.
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