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Comment
. 2012 Mar 7;31(5):1058-9.
doi: 10.1038/emboj.2012.39. Epub 2012 Feb 17.

B-type lamins and their elusive roles in metazoan cell proliferation and senescence

Christopher J Hutchison  1
Affiliations
Comment

B-type lamins and their elusive roles in metazoan cell proliferation and senescence

Christopher J Hutchison. EMBO J. .

Abstract

EMBO J 31 5, 1080–1094 (2012); published online January 13 2012

Have you seen the recent papers that question the traditional role of B-type lamins in DNA replication and transcription, but highlight an entirely novel yet fundamental role for lamin B1 (LB1) in cell proliferation and cellular senescence?

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Conflict of interest statement

The author declares that he has no conflict of interest.

Figures

Figure 1
Figure 1
The effects of different cellular stresses that lead to senescence on lamin A to lamin B1 ratios. Healthy early passage cells have a balanced LMA to LB1 ratio. In response to senescence-inducing events, LB1 expression is altered and/or LMA is oxidized, dramatically changing the ratio of LB1 to functional LMA, thus leading to altered lamina organization and entry into a state of senescence.
See this image and copyright information in PMC

Comment on

References

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