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Comment
. 2012 Feb 19;14(3):235-6.
doi: 10.1038/ncb2449.

Good neighbours in the tumour stroma reduce oxidative stress

Ralph J DeBerardinis  1
Affiliations
Comment

Good neighbours in the tumour stroma reduce oxidative stress

Ralph J DeBerardinis. Nat Cell Biol. .

Abstract

Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.

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