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Review
. 2011:76:291-8.
doi: 10.1101/sqb.2012.76.010439. Epub 2012 Feb 17.

NAD+ as a signaling molecule modulating metabolism

C Cantó  1 , J Auwerx
Affiliations
Review

NAD+ as a signaling molecule modulating metabolism

C Cantó et al. Cold Spring Harb Symp Quant Biol. 2011.

Abstract

The ability of NAD(+) to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD(+) levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD(+) have become highly relevant issues that we need to understand in order to elucidate how NAD(+) acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.

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