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Clinical Trial
. 2013 Jun-Jul;34(6):E61-4.
doi: 10.3174/ajnr.A2960. Epub 2012 Feb 16.

Visual cerebral microbleed detection on 7T MR imaging: reliability and effects of image processing

J de Bresser  1 , M Brundel, M M Conijn, J J van Dillen, M I Geerlings, M A Viergever, P R Luijten, G J Biessels
Affiliations
Clinical Trial

Visual cerebral microbleed detection on 7T MR imaging: reliability and effects of image processing

J de Bresser et al. AJNR Am J Neuroradiol. 2013 Jun-Jul.

Abstract

MR imaging at 7T has a high sensitivity for cerebral microbleed detection. We identified mIP processing conditions with an optimal balance between the number of visually detected microbleeds and the number of sections on 7T MR imaging. Even with optimal mIP processing, the limited size of some of the microbleeds and the susceptibility effects of other adjacent structures were a challenge for visual detection, which led to a modest inter-rater agreement, mainly due to missed microbleeds. Automated lesion-detection techniques may be required to optimally benefit from the increased spatial resolution offered by 7T MR imaging.

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Figures

Fig 1.
Fig 1.
Total number of microbleeds for mIP processing with and without an overlap. The left figure shows results of mIP processing without overlap but with differences in section thickness. The right figure shows the results of processing with overlap. The total number of detected microbleeds (possible and definite) is shown for all subjects, expressed as a percentage of maximum detected microbleeds within subjects.
Fig 2.
Fig 2.
Examples of microbleeds that are easy or hard to detect. This figure illustrates different microbleeds that were classified as definite microbleeds in the ground truth ratings. A and B, The TE 1 and TE 2 of the T2*-weighted 7T MR scan with a microbleed that was detected by all raters. The microbleed is seen on both the TE 1 and TE 2 images. C and D, A microbleed that was only detected by a few raters. This microbleed was only seen on the TE 2 image.
See this image and copyright information in PMC

References

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