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Comment
. 2012 Apr 15;302(8):L733-5.
doi: 10.1152/ajplung.00053.2012. Epub 2012 Feb 17.

Chloride in airway smooth muscle: the ignored anion no longer?

George Gallos  1 , Peter Yim, Charles W Emala
Affiliations
Comment

Chloride in airway smooth muscle: the ignored anion no longer?

George Gallos et al. Am J Physiol Lung Cell Mol Physiol. .

Abstract

This Perspectives accompanies an Editorial Focus that summarizes new developments concerning the role of chloride in airway smooth muscle physiology. We provide several observations and mechanistic insights to reconcile recent experimental evidence with existing paradigms concerning chloride channel-mediated effects on airway smooth muscle tone. In addition, we highlight the potentially complex and dynamic nature that chloride currents and membrane potential have on calcium handling and airway smooth muscle contractility.

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