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Review
. 2012 Mar;32(3):556-62.
doi: 10.1161/ATVBAHA.111.244608.

Critical review of mouse models of venous thrombosis

Jose A Diaz  1 , Andrea T Obi, Daniel D Myers Jr, Shirley K Wrobleski, Peter K Henke, Nigel Mackman, Thomas W Wakefield
Affiliations
Review

Critical review of mouse models of venous thrombosis

Jose A Diaz et al. Arterioscler Thromb Vasc Biol. 2012 Mar.

Abstract

Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to understand the pathophysiology of thrombogenesis and thrombus resolution, animal models are necessary. Mouse models of venous thrombosis contribute to our understanding of the initiation, propagation, and resolution of venous thrombus, as well as allow for the evaluation of new pharmaceutical approaches to prophylaxis and treatment of deep vein thrombosis. In this work we review the ferric chloride model, the inferior vena cava ligation model, the inferior vena cava stenosis models, and the electrolytic inferior vena cava model and compare their advantages and disadvantages.

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Figures

Figure 1
Figure 1
Schematic representation of stasis and flow models through acute venous thrombosis, sub-acute/chronic venous thrombosis, and chronic venous thrombosis.
Figure 2
Figure 2
Schematic representation of ligation, stenosis and electrolytic inferior vena cava (IVC) models. 1 indicates renal veins; 2, infrarenal IVC; 3, iliac veins.
See this image and copyright information in PMC

Comment in

References

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