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. 2012 Jan;44(1):73-7.
doi: 10.4103/0253-7613.91871.

Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats

Agadihiremath Vishwanatha Swamy  1 , Sumeet Gulliaya, Agadihiremath Thippeswamy, Basavaraj C Koti, Donnahalli V Manjula
Affiliations

Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats

Agadihiremath Vishwanatha Swamy et al. Indian J Pharmacol. 2012 Jan.

Abstract

Objectives: To study the preventive role of curcumin against doxorubicin (Dox)-induced myocardial toxicity in rats.

Materials and methods: Cardiotoxicity was produced by cumulative administration of Dox (15 mg/kg for two weeks). Curcumin (200 mg/kg, po) was administered as pretreatment for two weeks and then for two alternate weeks with Dox. The general observations, mortality, histopathology, biomarker enzymes like lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), biochemical parameters such as aspartate aminotransferase (AST) alanine aminotransferase (ALT) and alkaline phosphatase (ALP), antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were monitored after three weeks of last dose.

Results: The repeated administration of Dox induced cardiomyopathy associated with an antioxidant deficit and increased level biomarkers. Pretreatment with the curcumin significantly protected myocardium from the toxic effects of Dox by reducing the elevated level of biomarker enzymes like LDH and CPK and biochemical parameters such as AST, ALT and ALP back to normal. Curcumin increased the reduced level of GSH, SOD and CAT and decreased the elevated level of malondialdehyde (MDA) in cardiac tissue.

Conclusion: The biochemical and histopathology reports support the cardioprotective effect of curcumin which could be attributed to antioxidant.

Keywords: Antioxidant; cardiotoxicity; curcumin; doxorubicin; free radicals.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
(a) Photomicrograph of normal group heart showing normal myocardial fibers and architecture. (b) Doxorubicin-treated group showing loss of myocardial fibers and vacuolated cells. (c) Curcumin-treated group showing no vacuolated cells and myofibers loss and normal architecture. (d) Curcumin + doxorubicin treated group showing scanty myocardial fibers loss and vacuolated cells.
See this image and copyright information in PMC

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