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. 2012 Jan;44(1):124-5.
doi: 10.4103/0253-7613.91884.

Ceftriaxone-induced acute reversible encephalopathy in a patient with enteric fever

Affiliations

Ceftriaxone-induced acute reversible encephalopathy in a patient with enteric fever

Neetu Sharma et al. Indian J Pharmacol. 2012 Jan.

Abstract

Ceftriaxone is a commonly used, third-generation cephalosporin. Encephalopathy is a rare side effect of third- and fourth-generation cephalosporins. Renal failure and previous disease of the central nervous system predispose to this neurotoxicity. We describe a case of acute transient encephalopathy in a patient treated with ceftriaxone for enteric fever infection. Early detection of this complication is relevant given that stopping the drug usually reverts the neurological syndrome.

Keywords: Adverse drug reaction; ceftriaxone; encephalopathy; neurotoxicity.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Martínez-Rodríguez JE, Barriga FJ, Santamaria J, Iranzo A, Pareja JA, Revilla M, et al. Nonconvulsive status epilepticus associated with cephalosporins in patients with renal failure. Am J Med. 2001;111:115–9. - PubMed
    1. De Sarro A, Ammendola D, Zappala M, Grasso S, De Sarro GB. Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats. Antimicrobial Agents Chemother. 1995;39:232–7. - PMC - PubMed
    1. Eggers V, Fügener K, Hein OV, Rommelspacher H, Heyes MP, Kox WJ, et al. Antibiotic-mediated release of tumour necrosis factor alphain patients with hospital acquired pneumonia and septic encephalopathy. Intensive Care Med. 2004;30:1544–51. - PubMed
    1. Calandra G, Lydick E, Carrigan J, Weiss L, Guess H. Factors predisposing to seizures in seriously ill infected patients receiving antibiotics: Experience with imipenem/cilastatin. Am J Med. 1988;84:911–8. - PubMed
    1. Roncon-Albuquerque R, Jr, Pires I, Martins R, Real R, Sousa G, von Hafe P. Ceftriaxone-induced acute reversible encephalopathy in a patient treated for aurinary tract infection. Neth J Med. 2009;67:72–5. - PubMed