Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan;29(1):24-9.
doi: 10.4103/0970-2113.92358.

High sensitive C-reactive protein as a systemic inflammatory marker and LDH-3 isoenzyme in chronic obstructive pulmonary disease

Anup N Nillawar  1 , J S Bardapurkar, S J Bardapurkar
Affiliations

High sensitive C-reactive protein as a systemic inflammatory marker and LDH-3 isoenzyme in chronic obstructive pulmonary disease

Anup N Nillawar et al. Lung India. 2012 Jan.

Abstract

Background and objectives: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, mainly due to tobacco smoke. Pulmonary function tests (PFTs) are mandatory to diagnose COPD which shows irreversible airway obstruction. This study was aimed at understanding the behavior of biochemical parameters such as high sensitive C-reactive protein (hs-CRP) and lactate dehydrogenase (LDH) isoenzymes in COPD. Cytoplasmic cellular enzymes, such as LDH in the extracellular space, although of no further metabolic function in this space, are of benefit because they serve as indicators suggestive of disturbances of the cellular integrity induced by pathological conditions. The lung pattern is characterized by proportional increases in isoenzymes 3, 4, and 5. Hs-CRP indicates low grade of systemic inflammation.

Materials and methods: Total (n = 45) patients of COPD (diagnosed on PFTs) were included. We followed the guidelines laid by the institute ethical committee. Investigations performed on the serum were the serum for hs-CRP, LDH isoenzymes on agarose gel electrophoresis.

Results: The results obtained showed that the value of hs-CRP was 4.6 ± 0.42 mg/L. The isoenzymes pattern was characterized by an increase in LDH-3 and LDH-4 fractions. This is evident even in those patients with normal LDH (n = 13) levels.

Interpretation and conclusion: This study states that there is a moderate positive correlation in between CRP and LDH-3 (r = 0.33; P = 0.01). Raised LDH-3 levels do not correlate with FEV(1) % (forced expiratory volume in first second) predicted. Moreover, it associates positively with hs-CRP and smoking status and negatively with body mass index. This underlines the potential of these parameters to complement the present system of staging which is solely based upon FEV(1) % predicted.

Keywords: COPD; LDH-3 isoenzyme; hs-CRP.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Jindal SK, Aggarwal AN, Chaudhry K, Chhabra SK, D’Souza GA, Gupta D, et al. Multicentric Study on epidemiology of Chronic Obstructive Pulmonary Disease and its relationship with tobacco smoking and environmental tobacco smoke exposure. Indian J Chest Dis Allied Sci. 2006;48:23–9. - PubMed
    1. Goldcopd.com (Internet) 2005 update: executive Summary, Global Strategy for the Diagnosis, Management, and prevention of COPD. 2005. Sep, [Last accessed on 2005]. Available from: http://www.goldcopd.com/
    1. Groneberg DA, Chung KF. Models of chronic obstructive pulmonary disease. Respir Res. 2004;5:18. - PMC - PubMed
    1. Rufino R, Lapa e Silva JR. Cellular and biochemical bases of chronic obstructive pulmonary disease. J Bras Pneumol. 2006;32:241–8. - PubMed
    1. van Eeden SF, Yeung A, Quinlam K, Hogg JC. Systemic Response to Ambient Particulate Matter: Relevance to Chronic Obstructive Pulmonary Disease. Proc Am Thorac Soc. 2005;2:61–7. - PubMed