Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan;19(1):101-6.
doi: 10.4103/0974-9233.92124.

Incidence of retinopathy of prematurity and risk factors in the South-Western region of iran

Mostafa Feghhi  1 , Seyed Mohammad Hassan Altayeb, Foad Haghi, Ali Kasiri, Fereydoun Farahi, Mosoud Dehdashtyan, Mahzyar Movasaghi, Fakher Rahim
Affiliations

Incidence of retinopathy of prematurity and risk factors in the South-Western region of iran

Mostafa Feghhi et al. Middle East Afr J Ophthalmol. 2012 Jan.

Abstract

Aims: The aim of this study was to report the incidence of retinopathy of prematurity (ROP) and the contribution of various risk factors to ROP in the south-western region of Iran.

Material and methods: This cross-sectional case-control series reviewed all low birth weight (LBW, ≤2000 g) neonates and/or neonates less than 32 weeks gestational age who had been hospitalized in the Neonatal Intensive Care Unit from 2006 to 2010. The cohort was divided into infants without ROP (nonROP group) and infants with ROP (ROP group). Infants were first examined by a group of pediatric ophthalmologists 6 weeks after delivery, and then were followed every 1-2 weeks until death, discharge or complete retinal avascularization. If an infant developed ROP, further examinations were performed based on the Early Treatment for Retinopathy of Prematurity Study protocol. Demographic data, medical treatment, and ophthalmic disorders were all statistically analyzed.

Results: A total of 576 infants met the criteria for evaluation. Of 576 total patients, 183 infants (32%) (88 males, 95 females) had ROP. There were significant differences between groups in gestational age, body weight, and duration of oxygen administration, and sepsis (P<0.05). Male/female ratio, single and multiple births, and jaundice, phototherapy, and blood transfusion were not significant. The majority of ROP was stage I or II (137, 74.8%). Stage III or greater developed in 46 infants (25.1%) [Note: The ocular history and ocular outcomes are not risk factors.]

Conclusions: The incidence of ROP in this study is higher than that in other parts of the world. Awareness and knowledge of ROP and its relative risks need to be reinforced in ophthalmologists and other health practitioners.

Keywords: Incidence; Prematurity; Retinopathy; Risk Factors.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Schematic diagram of the cohort distribution of infants with and without retinopathy of prematurity in south-western Iran from 2006 to 2010
Figure 2
Figure 2
The distribution of gestational ages of infants with and without retinopathy of prematurity in south-western Iran from 2006 to 2010
Figure 3
Figure 3
The numbers of the different stages of ROP of infants with and without retinopathy of prematurity in south-western Iran from 2006 to 2010
Figure 4
Figure 4
Incidence of retinopathy of prematurity of infants with and without retinopathy of prematurity in southwestern Iran from 2006 to 2010
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. VanStone W. Retinopathy of prematurity: An example of a successful screening program. Neonatal Netw. 2010;29:15–21. - PubMed
    1. Hellström A, Engström E, Hård AL, Albertsson-Wikland K, Carlsson B, Niklasson A, et al. Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics. 2003;112:1016–20. - PubMed
    1. Quiram PA, Capone A., Jr Current understanding and management of retinopathy of prematurity. Curr Opin Ophthalmol. 2007;18:228–34. - PubMed
    1. Akula JD, Favazza TL, Mocko JA, Benador IY, Asturias AL, Kleinman MS, et al. The anatomy of the rat eye with oxygen-induced retinopathy. Doc Ophthalmol. 2010;120:41–50. - PubMed
    1. Sola A, Rogido MR, Deulofeut R. Oxygen as a neonatal health hazard: Call for détente in clinical practice. Acta Paediatr. 2007;96:801–12. Review. - PubMed