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. 2012 Jan;4(1):29-41.
doi: 10.3390/nu4010029. Epub 2012 Jan 4.

Combined fruit and vegetable intake is correlated with improved inflammatory and oxidant status from a cross-sectional study in a community setting

Martin M Root  1 , Megan C McGinn, David C Nieman, Dru A Henson, Serena A Heinz, R Andrew Shanely, Amy M Knab, Fuxia Jin
Affiliations

Combined fruit and vegetable intake is correlated with improved inflammatory and oxidant status from a cross-sectional study in a community setting

Martin M Root et al. Nutrients. 2012 Jan.

Abstract

Previous studies have examined the relationship between specific nutrient and food intakes with limited markers of either inflammation or oxidant status. The objective of this study was to determine if an increase in combined self-reported fruit and vegetable (F&V) intake in a community setting was associated with improved multiple markers of inflammatory and oxidant status. A community group (N = 1000, age 18-85 years, 61% female) gave two fasted blood samples separated by 12 weeks. Blood inflammatory biomarkers included total leukocytes (WBC), plasma C-reactive protein (CRP), interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1, and granulocyte colony stimulating factor. Measured oxidant status markers were ferric reducing ability of plasma (FRAP), oxygen radical absorbance capacity (ORAC) and plasma F₂-isoprostanes. The relation of markers across categories of F&V intake was examined. In analyses controlling for other important dietary and lifestyle factors, IL-6 and TNF-α were significantly lower across categories of increasing F&V intakes (p < 0.008). FRAP and ORAC were significantly higher (p < 0.0001 and p = 0.047 respectively) while F(2)-isoprostanes was significantly lower (p < 0.0001) across F&V categories. In a community study, several markers of both inflammation and oxidant status were associated in a putatively salutary direction by higher intake of combined F&V, supporting current guidelines suggesting increased F&V consumption for the prevention of chronic diseases.

Keywords: fruits; inflammation; oxidant status; vegetables.

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Figures

Figure 1
Figure 1
Comparison of category 3 to category 1 of combined fruit and vegetable intake for three biomarkers of inflammation and oxidative stress. For each marker the blue 100% bar represents the value of category 1 while the red bar represents category 3. The error bars are the 95% confidence intervals. The differences between category 1 and 3 for each marker are statistically significant at p ≤ 0.001.
See this image and copyright information in PMC

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