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Review
. 2013 Mar;75(3):619-29.
doi: 10.1111/j.1365-2125.2012.04216.x.

Clinical metabolomics paves the way towards future healthcare strategies

Sebastiano Collino  1 , François-Pierre J Martin, Serge Rezzi
Affiliations
Review

Clinical metabolomics paves the way towards future healthcare strategies

Sebastiano Collino et al. Br J Clin Pharmacol. 2013 Mar.

Abstract

Metabolomics is recognized as a powerful top-down system biological approach to understand genetic-environment-health paradigms paving new avenues to identify clinically relevant biomarkers. It is nowadays commonly used in clinical applications shedding new light on physiological regulatory processes of complex mammalian systems with regard to disease aetiology, diagnostic stratification and, potentially, mechanism of action of therapeutic solutions. A key feature of metabolomics lies in its ability to underpin the complex metabolic interactions of the host with its commensal microbial partners providing a new way to define individual and population phenotypes. This review aims at describing recent applications of metabolomics in clinical fields with insight into diseases, diagnostics/monitoring and improvement of homeostatic metabolic regulation.

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Figures

Figure 1
Figure 1
Biomarker applications in clinical settings. Clear opportunities are identified for improve health benefits and preventive medicine
See this image and copyright information in PMC

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