Review
Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine
Affiliations
- PMID: 22351663
Item in Clipboard
Review
Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine
In Vivo.
2012 Mar-Apr.
Abstract
Multidrug-resistant tuberculosis (MDRTB) infections that continue to increase in frequency globally have progressed to become extremely drug-resistant tuberculosis (XDRTB). The therapeutic problems associated with MDRTB pale in comparison to those for XDRTB where mortality is high. This mini-review highlights the evidence that supports the use of the phenothiazine neuroleptic thioridazine for the therapy of XDRTB. Although thioridazine does produce some serious side-effects, the poor prognosis associated with an XDRTB infection of a patient that presents with AIDS merits that the use of thioridazine for therapy of XDRTB is seriously considered. A recommended protocol is presented.
Similar articles
-
Mechanisms by which thioridazine in combination with antibiotics cures extensively drug-resistant infections of pulmonary tuberculosis.In Vivo. 2014 Mar-Apr;28(2):267-71. In Vivo. 2014. PMID: 24632985 Review.
-
The mechanism by which the phenothiazine thioridazine contributes to cure problematic drug-resistant forms of pulmonary tuberculosis: recent patents for "new use".Recent Pat Antiinfect Drug Discov. 2013 Dec;8(3):206-12. doi: 10.2174/1574891x08666131210141521. Recent Pat Antiinfect Drug Discov. 2013. PMID: 24320229 Review.
-
Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections.Int J Antimicrob Agents. 2012 May;39(5):376-80. doi: 10.1016/j.ijantimicag.2012.01.012. Epub 2012 Mar 23. Int J Antimicrob Agents. 2012. PMID: 22445204 Review.
-
Promising therapy of XDR-TB/MDR-TB with thioridazine an inhibitor of bacterial efflux pumps.Curr Drug Targets. 2008 Sep;9(9):816-9. doi: 10.2174/138945008785747798. Curr Drug Targets. 2008. PMID: 18781927 Review.
-
Therapy Of XDR TB with thioridazine a drug beyond patent protection but eligible for patent "as new use".Recent Pat Antiinfect Drug Discov. 2010 Jun;5(2):109-14. doi: 10.2174/157489110791233540. Recent Pat Antiinfect Drug Discov. 2010. PMID: 20156179
Cited by
-
Mechanisms of resistance in bacteria: an evolutionary approach.Open Microbiol J. 2013;7:53-8. doi: 10.2174/1874285801307010053. Epub 2013 Mar 22. Open Microbiol J. 2013. PMID: 23560029 Free PMC article.
-
Effect of thioridazine on erythrocytes.Toxins (Basel). 2013 Oct 23;5(10):1918-31. doi: 10.3390/toxins5101918. Toxins (Basel). 2013. PMID: 24152992 Free PMC article.
-
Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient.Pharmaceuticals (Basel). 2012 Sep 17;5(9):1021-31. doi: 10.3390/ph5091021. Pharmaceuticals (Basel). 2012. PMID: 24280703 Free PMC article.
-
Role of Phenothiazines and Structurally Similar Compounds of Plant Origin in the Fight against Infections by Drug Resistant Bacteria.Antibiotics (Basel). 2013 Feb 18;2(1):58-72. doi: 10.3390/antibiotics2010058. Antibiotics (Basel). 2013. PMID: 27029292 Free PMC article. Review.
-
Risk Factors for Poor Outcomes Among Patients with Extensively Drug-Resistant Tuberculosis (XDR-TB): A Scoping Review.Infect Drug Resist. 2021 Dec 16;14:5429-5448. doi: 10.2147/IDR.S339972. eCollection 2021. Infect Drug Resist. 2021. PMID: 34938089 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
