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. 2011 Nov;11(13):1122-9.
doi: 10.2174/138955711797655362.

Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine

Z-J Huang  1 , Y Zeng, P Lan, P-H Sun, W-M Chen
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Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine

Z-J Huang et al. Mini Rev Med Chem. 2011 Nov.

Abstract

Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.

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