Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Apr;59(4):763-8.
doi: 10.1161/HYPERTENSIONAHA.111.188342. Epub 2012 Feb 21.

Nontraditional roles of angiotensin-converting enzyme

Xiao Z Shen  1 , Frank S Ong, Ellen A Bernstein, Tea Janjulia, Wendell-Lamar B Blackwell, Kandarp H Shah, Brian L Taylor, Romer A Gonzalez-Villalobos, Sebastien Fuchs, Kenneth E Bernstein
Affiliations
Review

Nontraditional roles of angiotensin-converting enzyme

Xiao Z Shen et al. Hypertension. 2012 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None

Figures

Fig. 1
Fig. 1
Cross-immunization of WT and ACE KO mice. WT mice were immunized with peritoneal macrophages from either ACE WT or ACE KO mice. After 10 days, the recipient mice were sacrificed and splenocytes were expanded in vitro by restimulating with macrophages equivalent to those used for immunization. After 7 days, lymphocytes were again restimulated with macrophages equivalent to those used for immunization, but for 5 hrs. FACS analysis was then used to stain for CD8 and IFN-γ. The percentage of CD8+ cells that are IFNγhigh is indicated.
Fig. 2
Fig. 2
Tumor growth in ACE 10/10 mice. Wild type (WT), heterozygous (HZ) and ACE 10/10 mice were injected intradermally with 1 × 106 B16 melanoma cells. The mice were sacrificed 14 days later and tumor volume was determined. Each point is an individual mouse. Group means are also shown. Tumor growth in ACE 10/10 mice was greatly suppressed as compared to WT mice.
Fig. 3
Fig. 3
Tumor inflammation. Photos of blood vessels (long arrows) from melanomas in ACE 10/10 and WT mice. Many more mononuclear inflammatory cells are present in the blood vessels and the tumor (short arrow) of the ACE 10/10 mouse as compared to WT.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Paulis L, Unger T. Novel therapeutic targets for hypertension. Nature Reviews Cardiology. 2010;7:431–441. - PubMed
    1. Xiao HD, Fuchs S, Frenzel K, Teng L, Li P, Shen XZ, Adams J, Zhao H, Keshelava GT, Bernstein KE, Cole JM. The use of knockout mouse technology to achieve tissue selective expression of angiotensin converting enzyme. J Mol Cell Cardiol. 2004;36:781–789. - PubMed
    1. Matsusaka T, Miyazaki Y, Ichikawa I. The renin angiotensin system and kidney development. Annu Rev Physiol. 2002;64:551–561. - PubMed
    1. Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O’Brien DA, Smithies O. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 1995;375:146–148. - PubMed
    1. Esther CR, Jr, Howard TE, Marino EM, Goddard JM, Capecchi MR, Bernstein KE. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology and reduced male fertility. Lab Invest. 1996;74:953–965. - PubMed

Publication types

Substances