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Review
. 2012 Apr;59(4):763-8.
doi: 10.1161/HYPERTENSIONAHA.111.188342. Epub 2012 Feb 21.

Nontraditional roles of angiotensin-converting enzyme

Xiao Z Shen  1 , Frank S Ong, Ellen A Bernstein, Tea Janjulia, Wendell-Lamar B Blackwell, Kandarp H Shah, Brian L Taylor, Romer A Gonzalez-Villalobos, Sebastien Fuchs, Kenneth E Bernstein
Affiliations
Review

Nontraditional roles of angiotensin-converting enzyme

Xiao Z Shen et al. Hypertension. 2012 Apr.
No abstract available

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Conflict of interest statement

Conflict of Interest: None

Figures

Fig. 1
Fig. 1
Cross-immunization of WT and ACE KO mice. WT mice were immunized with peritoneal macrophages from either ACE WT or ACE KO mice. After 10 days, the recipient mice were sacrificed and splenocytes were expanded in vitro by restimulating with macrophages equivalent to those used for immunization. After 7 days, lymphocytes were again restimulated with macrophages equivalent to those used for immunization, but for 5 hrs. FACS analysis was then used to stain for CD8 and IFN-γ. The percentage of CD8+ cells that are IFNγhigh is indicated.
Fig. 2
Fig. 2
Tumor growth in ACE 10/10 mice. Wild type (WT), heterozygous (HZ) and ACE 10/10 mice were injected intradermally with 1 × 106 B16 melanoma cells. The mice were sacrificed 14 days later and tumor volume was determined. Each point is an individual mouse. Group means are also shown. Tumor growth in ACE 10/10 mice was greatly suppressed as compared to WT mice.
Fig. 3
Fig. 3
Tumor inflammation. Photos of blood vessels (long arrows) from melanomas in ACE 10/10 and WT mice. Many more mononuclear inflammatory cells are present in the blood vessels and the tumor (short arrow) of the ACE 10/10 mouse as compared to WT.
See this image and copyright information in PMC

References

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