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Comparative Study
. 1990 Oct 25;18(20):6045-7.
doi: 10.1093/nar/18.20.6045.

Host sequences flanking the HIV provirus

K A Vincent  1 , D York-Higgins, M Quiroga, P O Brown
Affiliations
Free PMC article
Comparative Study

Host sequences flanking the HIV provirus

K A Vincent et al. Nucleic Acids Res. .
Free PMC article

Abstract

A conserved property of retroviral proviruses is the presence of a direct repeat in the host DNA immediately flanking the viral sequence; each virus generates a repeat with a characteristic length. By sequencing the viral/host DNA junctions from five HIV-1 proviral clones, we have confirmed that integration of HIV results in the generation of a five basepair direct repeat. A target sequence in uninfected host DNA was analyzed to establish that the five basepair sequence flanking the provirus was present only once prior to integration. Of the five proviruses examined, two were found to have integrated in known repetitive sequence elements of the human genome; one in a Line-1 element and a second in satellite DNA.

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