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. 2011 Oct 21;3(4):e38.
doi: 10.4081/rt.2011.e38. Epub 2011 Dec 27.

Cytokeratin-negative small cell lung carcinoma

Tadashi Terada  1
Affiliations

Cytokeratin-negative small cell lung carcinoma

Tadashi Terada. Rare Tumors. .

Abstract

Cytokeratins (CK) are good markers of epithelial tumors, and most of carcinomas including small cell lung carcinoma (SCLC) expresses CK. Herein reported is a case of SCLC without CK expression.

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Figures

Figure 1
Figure 1
Chest computed tomography. A large tumor (10 cm in diameter) is seen in the anterior aspect of the right upper lobe.
Figure 2
Figure 2
Biopsy histology. The tumor cells are medullary and epithelioid. The tumor cells are small and had scant cytoplasm, hyperchromatic nuclei, and inconspicuous nucleoli. HE, A; x50. B;x200.
Figure 3
Figure 3
Immunohistocheimical findings. The tumor cells are positive for synaptophysin (A), PDGFRA (B), and Ki67 antigen (labeling=80%) (C). Immunostaining, x200.
See this image and copyright information in PMC

References

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