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Comment
. 2012 Mar 6;109(10):3608-9.
doi: 10.1073/pnas.1201029109. Epub 2012 Feb 22.

Nonovarian origins of ovarian cancer

Stephen G Hillier  1
Affiliations
Comment

Nonovarian origins of ovarian cancer

Stephen G Hillier. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Proposed fallopian tube origins of human ovarian and peritoneal epithelial carcinomas (key, Bottom). Studies of mice bearing dual Pten and Dicer gene KO reveal (labeled “1”) epithelial tumor formation in oviducts that (“2”) progresses to ipsilateral ovary, where it develops and thereafter (“3”) metastasizes throughout the peritoneal cavity. Note that translocation of oviductal tumor cells is initially confined to the ovarian surface by the surrounding bursa. By analogy, human tumor cells (“4”) arising in the fallopian tube epithelium can also (“5”) migrate to the adjacent ovarian surface epithelium and produce a tumor. However, they would also be free (“6”) to bypass the ovary and colonize other serosal surfaces in the peritoneal cavity as a result of the absence of a definite ovarian bursa. This might explain why high-grade serous peritoneal cancers can sometimes occur without macroscopic ovarian involvement.
See this image and copyright information in PMC

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References

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