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. 2012 May;108(1):179-85.
doi: 10.1007/s11060-012-0828-1. Epub 2012 Feb 23.

Patterns of failure after treatment of atypical meningioma with gamma knife radiosurgery

Albert Attia  1 , Michael D Chan, Ryan T Mott, Greg B Russell, David Seif, J Daniel Bourland, Allan F Deguzman, Thomas L Ellis, Kevin P McMullen, Michael T Munley, Stephen B Tatter, Edward G Shaw
Affiliations

Patterns of failure after treatment of atypical meningioma with gamma knife radiosurgery

Albert Attia et al. J Neurooncol. 2012 May.

Abstract

Atypical meningiomas have poor local control with emerging literature indicating the use of radiosurgery in treatment. The purpose of this study was to evaluate clinical outcomes including local control and failure pattern after Gamma Knife radiosurgery (GKRS) and factors that may affect these outcomes. Between 1999 and 2008, 24 patients were treated with GKRS as either primary or salvage treatment for pathologically proven atypical meningiomas. Treatment failures were determined by serial magnetic resonance imaging. A median marginal dose of 14 Gy was used (range 10.5-18 Gy). Overall local control rates at 1, 2, and 5 years were 75, 51, and 44%, respectively. With median follow-up time of 42.5 months, 14 of 24 patients experienced a treatment failure at time of last follow-up. Eight recurrences were in-field, four were marginal failures, and two were distant failures. Wilcoxon analysis revealed that the conformality index (CI) was a significant predictor of local recurrence (P = 0.04). CI did not predict for distant recurrences (P = 0.16). On multivariate analysis evaluating factors predicting progression free survival, dose >14 Gy was found to be statistically significant (P = 0.01). There appears to be a dose response using GKRS beyond 14 Gy but given the suboptimal local control rates in this study, higher doses may still be needed to obtain better local control.

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Conflict of interest statement

Conflict of Interest None of the authors has any personal, financial, or professional conflicts of interest to report.

Figures

Fig. 1
Fig. 1
Kaplan–Meier plot of time to local failure
Fig. 2
Fig. 2
Kaplan–Meier plot of overall survival
Fig. 3
Fig. 3
a Targeting of atypical meningioma. Axial SPGR MRI sequence with radiosurgical dose targeting enhancing tumor. The yellow line represents the 50% isodose line. The red line represents tumor delineation. b, c Follow-up MRI demonstrating marginal recurrence. b An axial SPGR MRI sequence. c Sagittal SPGR MRI sequence
See this image and copyright information in PMC

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