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. 2012;7(2):e31244.
doi: 10.1371/journal.pone.0031244. Epub 2012 Feb 16.

Th17-related genes and celiac disease susceptibility

Luz María Medrano  1 , Manuel García-Magariños, Bárbara Dema, Laura Espino, Carlos Maluenda, Isabel Polanco, M Ángeles Figueredo, Miguel Fernández-Arquero, Concepción Núñez
Affiliations

Th17-related genes and celiac disease susceptibility

Luz María Medrano et al. PLoS One. 2012.

Abstract

Th17 cells are known to be involved in several autoimmune or inflammatory diseases. In celiac disease (CD), recent studies suggest an implication of those cells in disease pathogenesis. We aimed at studying the role of genes relevant for the Th17 immune response in CD susceptibility. A total of 101 single nucleotide polymorphisms (SNPs), mainly selected to cover most of the variability present in 16 Th17-related genes (IL23R, RORC, IL6R, IL17A, IL17F, CCR6, IL6, JAK2, TNFSF15, IL23A, IL22, STAT3, TBX21, SOCS3, IL12RB1 and IL17RA), were genotyped in 735 CD patients and 549 ethnically matched healthy controls. Case-control comparisons for each SNP and for the haplotypes resulting from the SNPs studied in each gene were performed using chi-square tests. Gene-gene interactions were also evaluated following different methodological approaches. No significant results emerged after performing the appropriate statistical corrections. Our results seem to discard a relevant role of Th17 cells on CD risk.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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