Allosteric effects in a ditopic ligand containing bipyridine and tetra-aza-crown donor units

Abstract

Artificial allosterism: A ditopic ligand, which contains both bipyridine and tetra-aza-crown binding sites, coordinates one Cu(II) through all four N-donors of the tetradentate aza-crown unit. Reaction at the bipyridine site with another Cu(II) allosterically changes the aza-crown from being a tetradentate to a tridentate N-donor unit, a change in coordination mode that causes the successive binding of two Cu(II) ions to proceed with severe negative cooperativity (see scheme).