Polyunsaturated fatty acids and peripheral artery disease
- PMID: 22363018
- PMCID: PMC5798884
- DOI: 10.1177/1358863X11429175
Polyunsaturated fatty acids and peripheral artery disease
Abstract
There is substantial evidence that polyunsaturated fatty acids (PUFAs) such as n-3 and n-6 fatty acids (FAs) play an important role in prevention of atherosclerosis. In vitro and in vivo studies focusing on the interactions between monocytes and endothelial cells have explored the molecular effects of FAs on these interactions. Epidemiological surveys, followed by large, randomized, control trials have demonstrated a reduction in major cardiovascular events with supplementation of n-3 FAs in secondary prevention settings. The evidence of beneficial effects specific to patients with peripheral artery disease (PAD) remains elusive, and is the focus of this review.
Conflict of interest statement
None declared.
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