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. 2012 Feb 14;18(6):557-62.
doi: 10.3748/wjg.v18.i6.557.

Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

Hyung Hun Kim  1 , You Sun Kim, Yun Kyung Kang, Jeong Seop Moon
Affiliations

Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

Hyung Hun Kim et al. World J Gastroenterol. .

Abstract

Aim: To investigate the expressions of leptin and peroxisome proliferator-activated receptor γ (PPARG) in relation to body mass index (BMI).

Methods: We evaluated leptin and PPARG expression in 30 adenomas over 1 cm in size by immunohistochemical staining. In addition, clinicopathologic features including BMI were assessed.

Results: PPARG and leptin expression showed a strong positive correlation (P = 0.035). The average BMI of the leptin-positive group was higher than that of the leptin-negative group (25.4 ± 3.4 kg/m(2)vs 22.6 ± 2.4 kg/m(2), P = 0.018), and leptin expression was significantly correlated with high BMI (P = 0.024). Leptin expression was more frequently observed in intermediate/high grade dysplasia than in low grade dysplasia (P = 0.030). However, PPARG expression was not correlated with BMI and grade of dysplasia.

Conclusion: BMI has influenced on the leptin expression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.

Keywords: Body mass index; Colorectal adenoma; Leptin; Obesity; Peroxisome proliferator-activated receptor γ.

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Figures

Figure 1
Figure 1
Immunohistochemical detection of peroxisome-proliferator-activated receptor γ and leptin expression in colorectal adenomas. A and B: Strong nuclear expression of peroxisome-proliferator-activated receptor γ (PPARG) (A) and negative expression (B) in representative colorectal adenomas; C and D: Strong cytoplasmic expression of leptin (C) and negative expression (D) in representative colorectal adenomas. Original magnification:×200 (A-D).
Figure 2
Figure 2
Leptin and peroxisome-proliferator-activated receptor γ expression in colorectal adenomas and body mass index. A: The body mass index (BMI) of leptin positive group (25.4 ± 3.4 kg/m2) was significantly higher than the BMI of leptin negative group (22.6 ± 2.4 kg/m2, P = 0.018); B: There is no significant difference between the BMI of peroxisome-proliferator-activated receptor γ (PPARG) positive group (24.47 ± 0.75 kg/m2) and PPARG negative group (23.52 ± 0.87 kg/m2, P = 0.162).
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