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Comment
. 2012 Feb;10(2):e1001270.
doi: 10.1371/journal.pbio.1001270. Epub 2012 Feb 21.

Enzyme inhibitor may offer dual protection against brain disease

Charles Q Choi  1
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Comment

Enzyme inhibitor may offer dual protection against brain disease

Charles Q Choi. PLoS Biol. 2012 Feb.

Abstract

Genetic analysis in budding yeast and in cultured human astrocytes reveals that specific histone deacetylase complexes accelerate expansion mutations in DNA triplet repeats.

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Conflict of interest statement

The author has declared that no competing interests exist.

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Combined actions of HDACs and DNA repair outweigh HATs, resulting in expansions (a). But perturbing this situation, for example, adding an HDAC inhibitor (b), changes the outcome (stabilizing trinucleotide repeats).
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