Transcriptome comparison between fetal and adult mouse livers: implications for circadian clock mechanisms
- PMID: 22363607
- PMCID: PMC3283632
- DOI: 10.1371/journal.pone.0031292
Transcriptome comparison between fetal and adult mouse livers: implications for circadian clock mechanisms
Abstract
Microarray transcriptome analyses of fetal mouse liver did not detect circadian expression rhythms of clock genes or clock-controlled genes, although some rhythmic transcripts that were likely not driven by endogenous cellular clocks were identified. This finding reveals a key distinction between the circadian oscillators in fetal and adult mouse livers. Thus, in this study, the transcriptomes of fetal and adult livers were systematically compared to identify differences in the gene expression profiles between these two developmental stages. Approximately 1000 transcripts were differentially enriched between the fetal and adult livers. These transcripts represent genes with cellular functions characteristic of distinct developmental stages. Clock genes were also differentially expressed between the fetal and adult livers. Developmental differences in liver gene expression might have contributed to the differences in oscillation status and functional states of the cellular circadian clock between fetal and adult livers.
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References
-
- Ukai H, Ueda HR. Systems biology of mammalian circadian clocks. Annu Rev Physiol. 2010;72:579–603. - PubMed
-
- Panda S, Antoch MP, Miller BH, Su AI, Schook AB, et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 2002;109:307–320. - PubMed
-
- Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, et al. Extensive and divergent circadian gene expression in liver and heart. Nature. 2002;417:78–83. - PubMed
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